HCID 68979485, compound → HCID 68976360, compound

Participants

Reaction Steps

To a solution of 2-bromo-6,11-dihydro-11-methyl -5H-dibenzo[b,e]azepine (4, R8=Br; 32 g, 0.11 mol) in DCM, MnO2 (manganese oxide)(96.6 g, 1.11 mol) was added and the reaction mixture was allowed to stir overnight. The reaction mixture was filtered over decalite and concentrated under reduced pressure. The crude product was purified by column chromatography on silica (Heptane:Ethyl acetate=8:2) to give 2-bromo-11-methyl-11H-dibenzo[b,e]azepine (5, R8═Br; 29.4 g, 92%). Data: (m/z)=286/288 (M+H)+.

Provenance & Evidence