Triethylamine → HCID 131730935, compound

Participants

Reaction Steps

60 mg of 4-(benzylamino)-6-({4-[4-(2-hydroxyethyl)piperidin-1-yl]phenyl}amino)pyridine-3-carboxyamide (the compound of Example 57), 18 mg of triethylamine and 2 mg of 4-dimethylaminopyridine were dissolved in 5 mL of tetrahydrofuran, to which 18 mg of methanesulfonyl chloride was added under ice cooling, and stirred at the same temperature for 2 hours. Saturated aqueous sodium bicarbonate was added to the reaction mixture, extracted with chloroform, the extract was washed with water, and dried on anhydrous sodium sulfate. The solvent was evaporated and the residue was purified by silica gel thin layer chromatography (chloroform:methanol=5:1) to obtain 44 mg (62%) of the title compound as a light brown crystalline powder.

Provenance & Evidence