Triethylamine → HCID 131730942, compound

Participants

Reaction Steps

39 mg of 4-(benzylamino)-6-{(4-aminophenyl)amino) pyridine-3-carboxyamide (the compound of Example 65), 83 mg of 1-propanesulfonyl chloride and 67 mg of triethylamine in 1.5 mL of dichloromethane were stirred at room temperature for 1 hour. Under ice cooling, ammonia water was added to the reaction mixture, and stirred for 5 minutes. The reaction mixture was extracted with chloroform, and the extract was dried on anhydrous sodium sulfate. The solvent was evaporated and the residue was purified by silica gel column chromatography (chloroform:ammonia methanol=10:1) to obtain 12 mg (19%) of the title compound as a light brown crystalline powder.

Provenance & Evidence