HCID 131730950, compound → HCID 131730952, compound

Participants

Reaction Steps

229 mg of 6-{[4-(3-azidopropyl)phenyl]amino}-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide (the compound of Example 200) was dissolved in 30 mL of ethanol, to which 46 mg of 10% palladium carbon was added, and stirred under a hydrogen atmosphere at room temperature for 1 hour. The 10% palladium carbon was filtered off, the solvent was evaporated, and the residue was purified by silica gel column chromatography (chloroform:methanol=10:1 to chloroform:ammonia methanol=10:1) to obtain 161 mg (75%) of the title compound as a white crystalline powder.

Provenance & Evidence