Dimethylformamide → HCID 131730955, compound

Participants

Reaction Conditions

Reaction Steps

99 mg of 6-[(4-aminophenyl)amino]-4-(benzylamino) pyridine-3-carboxyamide (the compound of Example 65) and 44 mg of 4-bromobutyronitrile were added to 0.2 mL of N,N-dimethylformamide, and stirred at 70° C. for 1.5 hour. To the reaction mixture, saturated sodium bicarbonate in water was added, extracted with ethyl acetate, the extract was washed with saturated saline, and dried on anhydrous sodium sulfate. The solvent was evaporated, and the residue was purified by silica gel thin layer chromatography (chloroform:methanol=5:1) to obtain 59 mg (50%) of the title compound as a light brown powder.

Provenance & Evidence