Potassium Carbonate → HCID 131730960, compound

Participants

Reaction Conditions

Reaction Steps

120 mg of 4-[(2,3-difluorobenzyl)amino]-6-{[4-(piperazin-1-yl)phenyl]amino}pyridine-3-carboxyamide (the compound of Example 220), 72 mg of 2-bromoethyl-N,N-diethylamine.hydrobromide and 72 mg of potassium carbonate were added to 2 mL of N,N-diethylformamide, and stirred at 70° C. for 1.5 hour. The solvent was evaporated, and the residue was dissolved in chloroform, washed with saturated saline, and dried on anhydrous sodium sulfate. The solvent was evaporated, and the residue was purified by silica gel thin layer chromatography (chloroform:ammonia methanol=10:1) to obtain 74 mg (60%) of the title compound as a light brown powder.

Provenance & Evidence