Chloroform → HCID 131730964, compound

Participants

Reaction Steps

25 mg of 4-(benzylamino)-6-{[4-(1,4-diazepan-1-yl)phenyl]amino}pyridine-3-carboxyamide (the compound of Example 226) was dissolved in 0.3 mL of N,N-dimethylformamide, to which, under ice cooling, 10 mg of potassium carbonate and 4.3 mg of iodomethane were added, and stirred at the same temperature for 30 minutes and at room temperature for further 30 minutes. To the reaction mixture, chloroform was added, and the insoluble substances were filtered off. The solvent was evaporated and the residue was purified by silica gel thin layer chromatography (chloroform:ammonia methanol=10:1) to obtain 9 mg (35%) of the title compound as a light brown solid.

Provenance & Evidence