Acetone → HCID 131730965, compound

Participants

Reaction Steps

60 mg of 6-{[4-(1,4-diazepan-1-yl)phenyl]amino}-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide (the compound of Example 227) was suspended in 1.5 mL of chloroform, to which 0.2 mL of acetone, 4.1 mg of acetic acid and 58 mg of sodium triacetoxyborohydride were added, and stirred at room temperature for 4 hours. To the reaction mixture, saturated sodium bicarbonate in water was added, extracted with chloroform, and the extract was dried on anhydrous sodium sulfate. The solvent was evaporated, and the residue was purified by silica gel thin layer chromatography (chloroform:ammonia methanol=20:1), recrystallized from methanol-ether to obtain 37 mg (53%) of the title compound as a white crystalline powder.

Provenance & Evidence