Butyric Acid → HCID 575321, compound

HRID 2035509Notes

Reaction equation

HRID 2035509 reaction equation
[C:1]([OH:6])(=[O:5])[CH2:2][CH2:3][CH3:4].O[N:8]1[C:12](=[O:13])[CH2:11][CH2:10][C:9]1=[O:14].C1(N=C=NC2CCCCC2)CCCCC1>O1CCOCC1>[O:14]=[C:9]1[CH2:10][CH2:11][C:12](=[O:13])[N:8]1[O:5][C:1](=[O:6])[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 264Butyric AcidHCID 10868DicyclohexylcarbodiimideHCID 80170N-Hydroxysuccinimide

Product 1

HCID 575321HCID 575321, compoundYield 127.8%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

35 mg of butanoic acid was dissolved in 0.5 mL of 1,4-dioxane, to which 46 mg of N-hydroxysuccinimide and 82 mg of N,N′-dicyclohexylcarbodiimide were added, and stirred at room temperature for 1 hour. The deposit was filtered off, and the solvent was evaporated to obtain 94 mg of butanoic acid 2,5-dioxopyrrolidin-1-yl ester crude product. The crude product was used in the next reaction without further purification.

Workup

  1. additionwere added
  2. filtrationThe deposit was filtered off
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-dd846ff509b647358b7e73622a641888
Source dataset
uspto-grants-2013_11
Patent number
US08575153B2

Reaction notes

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