Water → HCID 131730983, compound

Participants

Reaction Conditions

Reaction Steps

12 mg of 4-(benzylamino)-6-({4-[(3-chloropropylsulfonyl)amino]phenyl}amino)pyridine-3-carboxyamide (the compound of Example 306) was dissolved in 1 mL of acetonitrile, to which 0.2 mL of diethylamine and 7 mg of potassium carbonate were added, and stirred at 80° C. for 1 hour. After cooling, water was added to the reaction mixture, extracted with chloroform, the extract was washed with saturated saline, and dried on anhydrous sodium sulfate. The solvent was evaporated, and the residue was purified by silica gel column chromatography (chloroform:methanol=10:1) to obtain 12 mg (100%) of the title compound as a brown crystalline powder.

Provenance & Evidence