1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 131730985, compound

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Reaction Steps

30 mg of 6-[(4-aminophenyl)amino]-4-(benzylamino) pyridine-3-carboxyamide (the compound of Example 65) was dissolved in 2 mL of methylene chloride, to which 25 mg of 1-(tert-butoxycarbonyl)-3-piperidine carboxylic acid, 21 mg of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and 13 mg of N,N-dimethylaminopyridine were added, and stirred overnight at room temperature. The reaction mixture was washed with water, and dried on anhydrous sodium sulfate. The solvent was evaporated, and the residue was purified by silica gel thin layer chromatography (chloroform:methanol) to obtain 38 mg (78%) of the title compound as a light pink crystalline powder.

Provenance & Evidence