反应详情

温度

100 °C

20 mg of 4-(benzylamino)-6-chloropyridine-3-carboxyamide (the compound of Example 1), 3.1 mg of [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium (II).methylene chloride adduct, 6.3 mg of 1,1′-bis (diphenylphosphino)ferrocene and 7.3 mg of sodium tert-butoxide were added to 1 mL of 1,4-dioxane, to which 18 mg of 4-(morpholinomethyl)aniline was added in an argon atmosphere, and stirred at 100° C. for 3 hours. The solvent was evaporated, and the residue was purified by silica gel thin layer chromatography (chloroform:ammonia methanol=10:1) to obtain 9 mg (28%) of the title compound as a light yellow powder.

1. additionwas added in an argon atmosphere
2. customThe solvent was evaporated
3. customthe residue was purified by silica gel thin layer chromatography (chloroform:ammonia methanol=10:1)