1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 131730992, compound

Participants

Reaction Steps

100 mg of 4-[(3,5-difluorobenzyl)amino]-6-[(4-morpholinophenyl)amino]pyridine-3-carboxylic acid was dissolved in 15 mL of dimethyl sulfoxide, to which 65.3 mg of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride and 52.2 mg of 1-hydroxybenzotriazole monohydrate were added at room temperature, and stirred at the same temperature for 2 hours. After the reaction was over, 2 mL of 2 mol/L ethylamine-THF solution was added, stirred overnight at room temperature. Then water was added, extracted with chloroform, the extract was washed with saturated saline, and dried on anhydrous sodium sulfate. The solvent was evaporated, and the residue was purified by silica gel thin layer chromatography (chloroform:methanol=10:1) to obtain 13.9 mg (13%) of the title compound as a light brown solid.

Provenance & Evidence