Hydrochloric Acid → HCID 131730997, compound

Participants

Reaction Steps

143.2 mg of 4-{[(1-benzylpyrrolidin-2-yl)methyl]amino}-6-[(4-morpholinophenyl)amino]pyridine-3-carboxyamide crude product (the compound of Example 357) was dissolved in 3 mL of ethanol, to which 103.1 mg of palladium hydroxide (II) and 0.3 mL of 2 mol/L hydrochloric acid in water were sequentially added, and stirred in a sealed tube at 40° C. in a hydrogen atmosphere at an initial pressure of 1 MPa for 12 hours. After cooling, the insoluble substances were filtered with celite, and the solvent was evaporated. The residue was dissolved in chloroform, washed with saturated sodium bicarbonate in water and saturated saline, and dried on anhydrous sodium sulfate. The solvent was evaporated, and the residue was purified by silica gel thin layer chromatography (chloroform:methanol-ammonia=8:1) to obtain 58.1 mg of the title compound as a light yellow crystalline powder.

Provenance & Evidence