HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-Diaminobenzonitrile → 6-[(2-Amino-5-cyanophenyl)amino]-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-Diaminobenzonitrile | HCID 737285 | — |
| Reactant | 6-Chloro-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide | HCID 131730949 | — |
| Reactant | 6-[(2-Amino-4-cyanophenyl)amino]-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide | HCID 131731004 | — |
| Product | 6-[(2-Amino-5-cyanophenyl)amino]-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide | HCID 131731003 | — |
Reaction Steps
From 6-chloro-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide (the compound of Example 20) and 4-cyano-1,2-phenylenediamine in a manner similar to step 1 of Example 365, a mixture of 6-[(2-amino-4-cyanophenyl)amino]-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide and 6-[(2-amino-5-cyanophenyl)amino]-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide (1H-NMR integral ratio 1:6) was obtained as a light yellow oil (yield 7%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575153B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-26be4c08adc84a90988d5ddb1044ac8d |
| Source note | uspto-grants-2013_11 |