HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl orthoformate → 6-(5-cyano-1H-benzimidazol-1-yl)-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl orthoformate | HCID 9005 | — |
| Reactant | 6-[(2-Amino-5-cyanophenyl)amino]-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide | HCID 131731003 | — |
| Reactant | 6-[(2-Amino-4-cyanophenyl)amino]-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide | HCID 131731004 | — |
| Product | 6-(5-cyano-1H-benzimidazol-1-yl)-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide | HCID 131731006 | — |
Reaction Steps
From the mixture of 6-[(2-amino-4-cyanophenyl)amino]-4-[(3,5-difluorobenzyl)amino]pyridine-3-carboxyamide and 6-[(2-amino-5-cyanophenyl)amino]-4-[(3,5-difluorobenzyl) amino]pyridine-3-carboxyamide (1H-NMR integral ratio 3:1) and trimethyl orthoformate in a manner similar to step 2 of Example 365, the title compound was obtained as a white solid (yield 45%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575153B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-a2b546bae12e46d5b0a73460dbafa222 |
| Source note | uspto-grants-2013_11 |