HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydrazinyl-4-(2-methoxyethoxy)pyridine → 8-(Tert-butyldimethylsilyloxy)-2-((2-(4-(2-methoxyethoxy)pyridin-2-yl)hydrazono)methyl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydrazinyl-4-(2-methoxyethoxy)pyridine | HCID 55279043 | — |
| Reactant | 8-(Tert-butyldimethylsilyloxy)quinoline-2-carbaldehyde | HCID 58567082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-(Tert-butyldimethylsilyloxy)-2-((2-(4-(2-methoxyethoxy)pyridin-2-yl)hydrazono)methyl)quinoline | HCID 67229769 | 56% |
Reaction Steps
2-Hydrazinyl-4-(2-methoxyethoxy)pyridine (0.076 g, 0.415 mmol) and 8-(tert-butyldimethylsilyloxy) quinoline-2-carbaldehyde (0.119 g, 0.415 mmol) were heated to reflux in EtOH (2 mL) for 16 hours. After cooling to ambient temperature the reaction mixture was filtered and washed with EtOH to provide 105 mg (56%) of desired product as an orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575145B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-7f9ab15340294252b86e196b0047593a |
| Source note | uspto-grants-2013_11 |