HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Hydrazinopyridine → 6-Fluoro-2-((2-(pyridin-2-yl)hydrazono)methyl)-8-(triisopropylsilyloxy)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Hydrazinopyridine | HCID 78645 | — |
| Reactant | 6-Fluoro-8-(triisopropylsilyloxy)quinoline-2-carbaldehyde | HCID 86638610 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Fluoro-2-((2-(pyridin-2-yl)hydrazono)methyl)-8-(triisopropylsilyloxy)quinoline | HCID 67229707 | 74% |
Reaction Steps
6-Fluoro-8-(triisopropylsilyloxy)quinoline-2-carbaldehyde (15.0 g, 43.2 mmol) and 2-hydrazinylpyridine (4.71 g, 43.2 mmol) were combined in 100 mL of anhydrous EtOH, and stirred at ambient temperature over night. Following over night stirring, the desired product was collected by filtration (washing with cold EtOH), affording 6-fluoro-2-((2-(pyridin-2-yl)hydrazono)methyl)-8-(triisopropylsilyloxy)quinoline (14.0 g, 31.9 mmol, 74% yield) as a yellow-white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575145B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-e8a7d3cf71404939aa765911e8f5fe75 |
| Source note | uspto-grants-2013_11 |