HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(R)-[1-(S)-benzyloxy-2-(S)-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-(S)-(3-methylbutyl)-morpholine-4-carboxylic acid tert-butyl ester → HCID 68558729, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(R)-[1-(S)-benzyloxy-2-(S)-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-(S)-(3-methylbutyl)-morpholine-4-carboxylic acid tert-butyl ester | HCID 68563802 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 68558729 | HCID 68558729 | 93% |
Reaction Steps
Dissolve 5-(R)-[1-(S)-benzyloxy-2-(S)-dibenzylamino-3-(3,5-difluorophenyl)-propyl]-2-(S)-(3-methylbutyl)-morpholine-4-carboxylic acid tert-butyl ester (187.7 mg, 0.263 mmol) in methanol (10 mL). Add 20% palladium hydroxide on carbon 100 mg) and hydrogenate at one atmosphere hydrogen gas for 18 hours. Add more 20% palladium hydroxide on carbon (100 mg) and further hydrogenate at one atmosphere hydrogen gas for 5 hours. Filter and concentrate to give the desired compound (107.8 mg, 93%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745438B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-d95a93a22df141bb8bf58a0f577d0c39 |
| Source note | uspto-grants-2010_06 |