tert-butyl N-(3-hydroxy-2,2-dimethylpropyl)carbamate → Tert-butyl 3-(2-(6-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yloxy)-2,2-dimethylpropylcarbamate

HRID 2035611Notes

Reaction equation

HRID 2035611 reaction equation
[OH:1][CH2:2][C:3]([CH3:14])([CH3:13])[CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9].[CH:15]1([C:18]2[CH:19]=[CH:20][C:21]3[N:22]([C:24]([C:27]4[CH:36]=[CH:35][C:34]5[C:29](=[C:30](O)[CH:31]=[CH:32][CH:33]=5)[N:28]=4)=[N:25][N:26]=3)[CH:23]=2)[CH2:17][CH2:16]1>>[CH:15]1([C:18]2[CH:19]=[CH:20][C:21]3[N:22]([C:24]([C:27]4[CH:36]=[CH:35][C:34]5[C:29](=[C:30]([O:1][CH2:2][C:3]([CH3:14])([CH3:13])[CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:9])([CH3:11])[CH3:10])[CH:31]=[CH:32][CH:33]=5)[N:28]=4)=[N:25][N:26]=3)[CH:23]=2)[CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 21263232tert-butyl N-(3-hydroxy-2,2-dimethylpropyl)carbamateHCID 1363378082-(6-Cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-ol

Product 1

HCID 67230907Tert-butyl 3-(2-(6-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-yloxy)-2,2-dimethylpropylcarbamate

Procedure

Prepared as described in Example 9, Step A, using tert-butyl 3-hydroxy-2,2-dimethylpropylcarbamate in place of tert-butyl-4-hydroxypiperidine-1-carboxylate and 2-(6-cyclopropyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-ol in place of 2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-ol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-46737206317a430784be610e785ca156
Source dataset
uspto-grants-2013_11
Patent number
US08575145B2

Reaction notes

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