tert-butyl N-(3-hydroxy-2,2-dimethylpropyl)carbamate → Tert-butyl 2,2-dimethyl-3-(2-(6-phenyl-[1,2,4]triazolo[4,3-a]pyridine-3-yl)quinolin-8-yloxy)propylcarbamate

HRID 2035613Notes

Reaction equation

HRID 2035613 reaction equation
[OH:1][CH2:2][C:3]([CH3:14])([CH3:13])[CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9].[C:15]1([C:21]2[CH:22]=[CH:23][C:24]3[N:25]([C:27]([C:30]4[CH:39]=[CH:38][C:37]5[C:32](=[C:33](O)[CH:34]=[CH:35][CH:36]=5)[N:31]=4)=[N:28][N:29]=3)[CH:26]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH3:13][C:3]([CH3:14])([CH2:2][O:1][C:33]1[CH:34]=[CH:35][CH:36]=[C:37]2[C:32]=1[N:31]=[C:30]([C:27]1[N:25]3[CH:26]=[C:21]([C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH:22]=[CH:23][C:24]3=[N:29][N:28]=1)[CH:39]=[CH:38]2)[CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:9])([CH3:11])[CH3:10]

Participants

3

Reactant 2

HCID 21263232tert-butyl N-(3-hydroxy-2,2-dimethylpropyl)carbamateHCID 1363378092-(6-Phenyl-[1,2,4]triazolo[4,3-a]pyridin-3-yl)quinolin-8-ol

Product 1

HCID 67230353Tert-butyl 2,2-dimethyl-3-(2-(6-phenyl-[1,2,4]triazolo[4,3-a]pyridine-3-yl)quinolin-8-yloxy)propylcarbamate

Procedure

Prepared as described in Example 9, Step A, using tert-butyl 3-hydroxy-2,2-dimethylpropylcarbamate in place of tert-butyl-4-hydroxypiperidine-1-carboxylate and 2-(6-phenyl-[1,2,4]triazolo[4,3-a]pyridine-3-yl)quinolin-8-ol in place of 2-([1,2,4]triazolo[4,3-a]pyridine-3-yl)quinolin-8-ol.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-af62f305bd014c61ae2772f255dc14d1
Source dataset
uspto-grants-2013_11
Patent number
US08575145B2

Reaction notes

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