反应详情

温度

160 °C

Solid N-(2,4-difluorophenyl)cinnamamide (13.2 g, 50.7 mmol) was pre-mixed with aluminum trichloride (20.29 g, 152.2 mmol) and the mixture was heated to 160° C. under gently flowing nitrogen gas for 80 minutes. The reaction was cooled and quenched with ice, and the resultant beige solid was collected by filtration, washed with water and air-dried to a light tan solid (9.89 g).

1. temperatureThe reaction was cooled
2. customquenched with ice
3. filtrationthe resultant beige solid was collected by filtration
4. washwashed with water
5. dry with materialair-dried to a light tan solid (9.89 g)