HRID2035651

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID149026

Tetrafluoro-m-phenylenediamine dihydrochloride

C6H6Cl2F4N2

HCID66782031

Quinoline, 8-[[(3R,4R)-3-fluoro-4-piperidinyl]oxy]-, rel-

C14H15FN2O

结构：F[C@@H]1CNCC[C@H]1Oc1cccc2ccc(-c3nnc4ccccn34)nc12

HCID67230123

未命名化合物

PRODUCTS

生成物

结构：Cl.Cl.F[C@@H]1CNCC[C@H]1Oc1cccc2ccc(-c3nnc4ccccn34)nc12

HCID67234475

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Preparation of the dihydrochloride salt of Enantiomer 2 of 2-k [1,2,4]triazolo[4,3-a]pyridin-3-yl)-8-((trans)-3-fluoropiperidin-4-yloxy)quinoline: Prepared as described in Example 94 using non-racemic 2-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-8-((trans)-3-fluoropiperidin-4-yloxy)quinoline in Step 4C. Specific rotation: [α]20D=+2.7° (c=0.45, 1:1 water/95% ethanol).

WORKUP

后处理

customPrepared