tert-Butyl 4-ethynylpiperidine-1-carboxylate → tert-Butyl 4-{1-[6-fluoro-2-oxo-1-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]-1H-1,2,3-triazol-4-yl}piperidine-1-carboxylate

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Reaction Steps

tert-Butyl 4-{1-[6-fluoro-2-oxo-1-(2,2,2-trifluoroethyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-3-yl]-1H-1,2,3-triazol-4-yl}piperidine-1-carboxylate was prepared from tert-butyl 4-ethynylpiperidine-1-carboxylate (synthesized from tert-butyl 4-formylpiperidine-1-carboxylate and Bestmann's reagent under standard condition) and 3-azido-6-fluoro-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one under standard click chemistry condition. MS calculated 512.2 (MH+), exp 521.1 (MH+).

Provenance & Evidence