Cesium carbonate → HCID 58063592, compound

Participants

Reaction Steps

3-[4-(5-Bromopyrimidin-2-yl)-1H-1,2,3-triazol-1-yl]-6-fluoro-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (75 mg, 0.155 mmol), 4-pyridineboronic acid (28.5 mg, 0.232 mmol), Pd2(dba)3 (7.08 mg, 7.73 μmol), cesium carbonate (101 mg, 0.309 mmol), and X-phos (7.37 mg, 0.015 mmol) were combined in a microwave vial along with water (0.5 mL) and 1,4-dioxane (0.9 mL). The vessel was irradiated for 15 mins at 140° C. The vial was allowed to cool before being diluted with EtOAc and syringe filtered. The filtrate was concentrated and purified on column chromotagraphy to yield the desired product, 11 mg.

Provenance & Evidence