HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-fluoro-3-{4-[2-fluoro-4-(pyridin-4-yl)-phenyl]-1H-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one → 6-fluoro-3-{4-[4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]-1H-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-fluoro-3-{4-[2-fluoro-4-(pyridin-4-yl)-phenyl]-1H-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one | HCID 58063608 | — |
| Reactant | 5-(4-Ethynyl-phenyl)-3-methyl-1,2,4-oxadiazole | HCID 77231329 | — |
| Product | 6-fluoro-3-{4-[4-(3-methyl-1,2,4-oxadiazol-5-yl)phenyl]-1H-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one | HCID 46841426 | — |
Reaction Steps
The title compound was prepared by the same route as 6-fluoro-3-{-4-[2-fluoro-4-(pyridin-4-yl)phenyl]-1H-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one, using 5-(4-ethynyl-phenyl)-3-methyl-1,2,4-oxadiazole as the alkyne.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575150B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-c5abc1ca225a49ce892de78b5aeaa599 |
| Source note | uspto-grants-2013_11 |