Diisopropylethylamine → HCID 58063525, compound

Participants

Reaction Steps

In a sealed tube, 6-fluoro-3-[4-(piperidin-4-yl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (50 mg, 0.122 mmol), 4-chloropyrimidine hydrochloride (27.5 mg, 0.182 mmol) and DIEA (212 uL, 1.215 mmol) in 2-propanol (1.2 mL) was heated at 140° C. for 1 h. After cooling to ambient temperature and solvent removal under reduced pressure, the residue was purified by column chromatography on silica gel to afford 46 mg title compound.

Provenance & Evidence