6-fluoro-3-(4-{4-[(2-methylpyridin-3-yl)oxy]phenyl}-1H-1,2,3-triazol-1-yl)-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one → 3-(4-{4-[(2,6-dimethylpyridin-4-yl)oxy]phenyl}-1H-1,2,3-triazol-1-yl)-6-fluoro-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

HRID 2035720Notes

Reaction equation

HRID 2035720 reaction equation
[F:1][C:2]1[C:7]2[CH2:8][CH2:9][CH:10]([N:19]3[CH:23]=[C:22]([C:24]4[CH:29]=[CH:28][C:27]([O:30]C5C(C)=NC=CC=5)=[CH:26][CH:25]=4)[N:21]=[N:20]3)[C:11](=[O:18])[N:12]([CH2:13][C:14]([F:17])([F:16])[F:15])[C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH3:38][C:39]1[CH:44]=[C:43](O)[CH:42]=[C:41]([CH3:46])[N:40]=1>>[CH3:38][C:39]1[CH:44]=[C:43]([O:30][C:27]2[CH:28]=[CH:29][C:24]([C:22]3[N:21]=[N:20][N:19]([CH:10]4[CH2:9][CH2:8][C:7]5[C:2]([F:1])=[CH:3][CH:4]=[CH:5][C:6]=5[N:12]([CH2:13][C:14]([F:17])([F:16])[F:15])[C:11]4=[O:18])[CH:23]=3)=[CH:25][CH:26]=2)[CH:42]=[C:41]([CH3:46])[N:40]=1

Participants

3

Reactant 2

HCID 468417266-fluoro-3-(4-{4-[(2-methylpyridin-3-yl)oxy]phenyl}-1H-1,2,3-triazol-1-yl)-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-oneHCID 178429033HCID 178429033, compound

Product 1

HCID 580636203-(4-{4-[(2,6-dimethylpyridin-4-yl)oxy]phenyl}-1H-1,2,3-triazol-1-yl)-6-fluoro-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

Procedure

Prepared as for 6-fluoro-3-(4-{4-[(2-methylpyridin-3-yl)oxy]phenyl}-1H-1,2,3-triazol-1-yl)-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one, using 2,6-dimethyl-4-hydroxypyridine.

Sources & evidence

ORD record
ord-15dd4337a1714506ba5a364c9e79e7d1
Source dataset
uspto-grants-2013_11
Patent number
US08575150B2

Reaction notes

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