HCID 58063545, compound → HCID 58063612, compound

HRID 2035724Notes

Reaction equation

[CH2:1]([C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[N:16]=[N:17][N:18]([CH:20]4[CH2:26][CH2:25][C:24]5[CH:27]=[CH:28][CH:29]=[CH:30][C:23]=5[N:22]([CH2:31][C:32]([F:35])([F:34])[F:33])[C:21]4=[O:36])[CH:19]=3)=[CH:11][C:10]=2[O:37][CH3:38])[CH:6]=[CH:5][N:4]=1)[CH3:2].[CH:39]([Mg]Br)(C)C.ClC1C=C(C2C=CC(C3N=NN(C4CCC5C=CC=CC=5N(CC(F)(F)F)C4=O)C=3)=CC=2OC)C=CN=1>>[CH:1]([C:3]1[CH:8]=[C:7]([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[N:16]=[N:17][N:18]([CH:20]4[CH2:26][CH2:25][C:24]5[CH:27]=[CH:28][CH:29]=[CH:30][C:23]=5[N:22]([CH2:31][C:32]([F:35])([F:34])[F:33])[C:21]4=[O:36])[CH:19]=3)=[CH:11][C:10]=2[O:37][CH3:38])[CH:6]=[CH:5][N:4]=1)([CH3:39])[CH3:2]

Participants

Reactant 3

HCID 58063545HCID 58063545, compound

HCID 58063577HCID 58063577, compound

HCID 178418365HCID 178418365, compound

Product 1

HCID 58063612HCID 58063612, compound

Procedure

3-{4-[4-(2-Isopropylpyridin-4-yl)-3-methoxyphenyl]-1H-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one was prepared by using the same procedure described for 3-{4-[4-(2-ethylpyridin-4-yl)-3-methoxyphenyl]-1H-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one with isopropyl magnesium bromide (1M in THF, 189 μl, 0.189 mmol), and 3-{4-[4-(2-chloropyridin-4-yl)-3-methoxyphenyl]-1H-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (50 mg, 0.095 mmol).

Sources & evidence

ORD record: ord-5595fe4ab2ca4bd1855058d499850440
Source dataset: uspto-grants-2013_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08575150B2

Reaction notes

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