Potassium Phosphate, Tribasic → HCID 58063511, compound

Participants

Reaction Steps

3-[4-(3-Chlorophenyl)-1H-1,2,3-triazol-1-yl]-6-fluoro-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one (30 mg, 0.068 mmol), pyridin-3-ylboronic acid (12.67 mg, 0.103 mmol), palladium acetate (3.07 mg, 0.014 mmol), potassium phosphate tribasic (29.0 mg, 0.137 mmol), and S-Phos (8.42 mg, 0.021 mmol) were added to a microwave vial. The reactants were suspended in THF (414 μL) and H2O (41 μL) and the vial sealed. The reaction mixture was irradiated at 120° C. in the microwave for 10 minutes, The completed reaction was filtered and concentrated in vacuo. Analytically pure material was obtained by purification by preparative HPLC Reverse phase (C-18), eluting with acetonitrile/water+0.05% Formic Acid. Lyophilisation afforded 6-fluoro-3-[4-(3-pyridin-3-ylphenyl)-1H-1,2,3-triazol-1-yl]-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one.

Provenance & Evidence