Sulfuric Acid → HCID 86663613, compound

HRID 2035748Notes

Reaction equation

HRID 2035748 reaction equation
[F:1][C:2]1([F:16])[O:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]#[N:13])=[CH:11][C:5]=2[O:4][C:3]1([F:15])[F:14].S(=O)(=O)(O)[OH:18]>O>[F:16][C:2]1([F:1])[O:7][C:6]2[CH:8]=[CH:9][C:10]([C:12]([NH2:13])=[O:18])=[CH:11][C:5]=2[O:4][C:3]1([F:14])[F:15]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 27766192,2,3,3-Tetrafluoro-6-nitrilobenzodioxene

Product 1

HCID 86663613HCID 86663613, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
40 °C

Procedure

To 2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b][1,4]dioxine-6-carbonitrile (200 mg) were added concentrated sulfuric acid (2 mL) and water (0.3 mL) at room temperature. The reaction mixture was stirred at 40° C. for 3 hr, water was added and the mixture was stirred for 40 min at room temperature. The resulting solid was collected by filtration, washed with purified water, and dried under reduced pressure to give the title compound (190.6 mg).

Workup

  1. stirringthe mixture was stirred for 40 min at room temperature
  2. filtrationThe resulting solid was collected by filtration
  3. washwashed with purified water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-a2994967f4564fc18f8c4f408afcdb76
Source dataset
uspto-grants-2013_11
Patent number
US08575154B2

Reaction notes

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