Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Propane, 1-iodo-2,2-dimethyl- | HCID 84953 | — |
| Reactant | 4-(2,2-Dioxido-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazin-9-yl)phenol | HCID 66747817 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 66748059 | HCID 66748059 | 72.6% |
Reaction Steps
A mixture of potassium carbonate (300 mg), 1-iodo-2,2-dimethylpropane (430 mg) and 4-(2,2-dioxido-3,4-dihydropyrido[2,1-c][1,2,4]thiadiazin-9-yl)phenol (200 mg) in DMSO (5 mL) was stirred at 150° C. for 1 hr. Water was added to give a precipitate. The precipitate was collected by filtration and washed with Et2O-water. The precipitate was crystallized from CH3CN-IPE to give the title compound (182 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08575154B2 |
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| Source dataset | uspto-grants-2013_11 |
|---|
| ORD ID | ord-5d76c4991e1f44c0b3110a3a4d7ec1f3 |
|---|
| Source note | uspto-grants-2013_11 |
|---|
