関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 2-Amino-3-chloropyrazine | HCID 276224 | — |
| 反応物 | 4-Cyclohexyloxy-benzeneboronic acid | HCID 22289818 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 生成物 | 3-[4-(Cyclohexyloxy)phenyl]pyrazin-2-amine | HCID 66748148 | 77.8% |
反応手順
A mixture of sodium carbonate (491 mg), tetrakis(triphenylphosphine)palladium(0) (80 mg), 4-(cyclohexyloxy)phenylboronic acid (612 mg) and 3-chloropyrazin-2-amine (300 mg) in water (3 mL) and DME (15 mL) was stirred at 80° C. for 4 hr. Silica gel was added and the mixture was concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with EtOAc in hexane) to give 3-[4-(cyclohexyloxy)phenyl]pyrazin-2-amine (485 mg) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08575154B2 |
|---|
| 出典データセット | uspto-grants-2013_11 |
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| ORD ID | ord-ce29652cb9804afaa485558ed6eac362 |
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| 出典メモ | uspto-grants-2013_11 |
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