Ethanesulfonylchloride, 2-chloro- → HCID 56655832, compound

Participants

Reaction Steps

To a suspension of NaH (60%, 1.57 g) in THF (dry) (60 ml) was added 2-chloroethanesulfonyl chloride (1.652 mL) at 0° C. and the mixture was stirred for 10 min at the same temperature. A solution of 3-(4-(4-methylphenoxy)phenyl)pyridin-2-amine (2.17 g) in THF (dry) (40 mL) was added at 0° C. and the mixture was stirred at room temperature under nitrogen overnight. The mixture was quenched with water at 0° C. Water, EtOAc and IPE were added and the precipitates were collected, washed with water/EtOAc, and dried in vacuo. The precipitates were crystallized from DMSO (15 mL)/EtOH (200 ml) at 80° C. to room temperature to give the title compound (1.91 g) as colorless crystals.

Provenance & Evidence