methyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-hydroxypropyl)thiazole-4-carboxylate → methyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-hydroxypropyl)thiazole-4-carboxylate

HRID 203596Notes

Reaction equation

HRID 203596 reaction equation
[s:1]1[c:2]2[cH:3][cH:4][cH:5][cH:6][c:7]2[n:8][c:9]1[NH:10][C:11]([c:12]1[cH:13][cH:14][cH:15][c:16]2[c:17]1[CH2:18][N:19]([c:20]1[s:21][c:22]([CH2:23][CH2:24][CH2:25][OH:26])[c:27]([C:28]([O:29][CH3:30])=[O:31])[n:32]1)[CH2:33][CH2:34]2)=[O:35].[s:36]1[c:37]([N:45]([C:46](=[O:47])[c:48]2[cH:49][cH:50][cH:51][c:52]3[c:57]2[CH2:56][N:55]([c:58]2[s:59][c:60]([C:67]#[C:68][CH2:69][OH:70])[c:61]([C:63](=[O:64])[O:65][CH3:66])[n:62]2)[CH2:54][CH2:53]3)[CH2:71][O:72][CH2:73][CH2:74][Si:75]([CH3:76])([CH3:77])[CH3:78])[n:38][c:39]2[c:40]1[cH:41][cH:42][cH:43][cH:44]2>>[s:36]1[c:37]([N:45]([C:46](=[O:47])[c:48]2[cH:49][cH:50][cH:51][c:52]3[c:57]2[CH2:56][N:55]([c:58]2[s:59][c:60]([CH2:67][CH2:68][CH2:69][OH:70])[c:61]([C:63](=[O:64])[O:65][CH3:66])[n:62]2)[CH2:54][CH2:53]3)[CH2:71][O:72][CH2:73][CH2:74][Si:75]([CH3:76])([CH3:77])[CH3:78])[n:38][c:39]2[c:40]1[cH:41][cH:42][cH:43][cH:44]2

Participants

3

Reactant 2

HCID 59447541methyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-hydroxypropyl)thiazole-4-carboxylateHCID 59447677methyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-hydroxyprop-1-ynyl)thiazole-4-carboxylate

Product 1

HCID 59447477methyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-hydroxypropyl)thiazole-4-carboxylate

Sources & evidence

ORD record
ord-662b4763f3a7468c960f47fa4beb8fc6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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