HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2035976Generated: October 27, 2026
Sodium Carbonate → 5-Methyl-3-(4-phenoxyphenyl)pyrazin-2-amine
https://huagongshe.com/reaction/2035976
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-Phenoxyphenylboronic acid | HCID 2734377 | — |
| Reactant | 2-Amino-3-bromo-5-methylpyrazine | HCID 9899043 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 5-Methyl-3-(4-phenoxyphenyl)pyrazin-2-amine | HCID 66748055 | 92.9% |
Reaction Steps
A mixture of sodium carbonate (122 mg), tetrakis(triphenylphosphine)palladium(0) (33.2 mg), 4-phenoxyphenylboronic acid (160 mg) and 3-bromo-5-methylpyrazin-2-amine (108 mg) in DME (10 mL) and water (3 mL) was stirred at 80° C. overnight. The mixture was added with silica gel, concentrated in vacuo, and purified by column chromatography (silica gel, eluted with EtOAc in hexane) to give the title compound (148 mg) as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08575154B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-7ac48a2d5f364d9cb4780812b07c80d6 |
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| Source note | uspto-grants-2013_11 |
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