HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → HCID 66748635, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | (3,4,5-Trifluorophenyl)boronic Acid (contains varying amounts of Anhydride) | HCID 2734671 | — |
| Reactant | 4-[(9S)-2,2-dioxido-3,4,6,7,8,9-hexahydropyrido[2,1-c][1,2,4]thiadiazin-9-yl]phenol | HCID 66748496 | — |
| Catalyst | HCID 178476681 | HCID 178476681 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 66748635 | HCID 66748635 | 13.4% |
Reaction Steps
A mixture of (3,4,5-trifluorophenyl)boronic acid (1882 mg), 4-[(9S)-2,2-dioxido-3,4,6,7,8,9-hexahydropyrido[2,1-c][1,2,4]thiadiazin-9-yl]phenol (1000 mg), pyridine (7.21 mL), cesium carbonate (1162 mg), diacetoxycopper (1296 mg) and powdered 4A MS (10.0 g) in MeCN (36 mL) was stirred at room temperature overnight. The mixture was added with NH silica gel, concentrated in vacuo, and purified by column chromatography (NH silica gel, eluted with MeOH in EtOAc) then recrystallized from EtOAc to give the title compound (196 mg) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575154B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-61531063d6864f7f9ccb2d461bfa6e05 |
| Source note | uspto-grants-2013_11 |