HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2036006Generated: October 25, 2026
Water → 5-Methyl-3-(3-phenoxyazetidin-1-yl)pyrazin-2-amine
https://huagongshe.com/reaction/2036006
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Amino-3-bromo-5-methylpyrazine | HCID 9899043 | — |
| Reactant | 3-Phenoxyazetidine | HCID 12812501 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-Methyl-3-(3-phenoxyazetidin-1-yl)pyrazin-2-amine | HCID 68280934 | 35.2% |
Reaction Steps
Potassium carbonate (18.53 mg) was added to a mixture of 3-phenoxyazetidine (20 mg) and 3-bromo-5-methylpyrazin-2-amine (25 mg) in DMF (dry) (1 mL). The mixture was stirred at 120° C. for 4 hr. Water and EtOAc were added and the extracted organic layer was washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuo. The residue was purified by column chromatography (silica gel, eluted with EtOAc in hexane) to give the title compound (12 mg) as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08575154B2 |
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| Source dataset | uspto-grants-2013_11 |
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| ORD ID | ord-2171b970bb32498788cbdf06a351d046 |
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| Source note | uspto-grants-2013_11 |
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