Lithium Hydroxide → HCID 44253223, compound

Participants

Reaction Steps

To a solution of 5-[4-(2,6-Dichloro benzyl)-piperazine-1-yl]-4-methyl-benzofuran-2-carboxylic acid ethyl ester (0.08 g, 0.0001 mol) in THF:Water:Methanol (3:2:1) mixture (19 ml) was added lithium hydroxide (0.02 g, 0.0005 mol) at 0° C. The reaction mixture was stirred for 2 hours. The completion of the reaction was confirmed by TLC. Solvent was concentrated under reduced pressure added ice water. The pH of the mixture was made acidic with 1N HCl and the solid separated was filtered. After drying under vacuum, isolated 5-[4-(2,6-Dichloro benzyl)-piperazine-1-yl]-4-methyl-benzofuran-2-carboxylic acid (70 mg, 94%).

Provenance & Evidence