HCID 335465, compound → 1'H-Spiro[piperidine-4,2'-quinazolin]-4'(3'H)-one

HRID 2036076Notes

Reaction equation

HRID 2036076 reaction equation
C([N:8]1[CH2:23][CH2:22][C:11]2([NH:20][C:19](=[O:21])[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[NH:12]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>CO.[C].[Pd]>[NH:12]1[C:13]2[C:18](=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:19](=[O:21])[NH:20][C:11]21[CH2:22][CH2:23][NH:8][CH2:9][CH2:10]2

Participants

4

Reactant 1

HCID 335465HCID 335465, compound

Product 1

HCID 258050621'H-Spiro[piperidine-4,2'-quinazolin]-4'(3'H)-oneYield 66.2%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

1-Benzyl-1′H-spiro[piperidine-4,2′-quinazolin]-4′ (3′H)-one (5.0 g) and 10% palladium-carbon (500 mg) were suspended in methanol (200 mL), and the suspension was stirred at room temperature for 2 days under a hydrogen atmosphere. The catalyst was removed by filtration through celite. The solvent was evaporated under reduced pressure and the residue was crystallized from ethanol/ether to give the object product (2.34 g, 41%).

Workup

  1. customThe catalyst was removed by filtration through celite
  2. customThe solvent was evaporated under reduced pressure
  3. customthe residue was crystallized from ethanol/ether

Sources & evidence

ORD record
ord-40a30727816c4c00b2bd0abfa34195d7
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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