3-Fluoroaniline → HCID 56773836, compound

HRID 2036096Notes

Reaction equation

HRID 2036096 reaction equation
[O:1]1[C:3]2([CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:10])[CH2:5][CH2:4]2)[CH2:2]1.[F:19][C:20]1[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=1)[NH2:23].Cl([O-])(=O)(=O)=O.[Li+]>>[F:19][C:20]1[CH:21]=[C:22]([NH:23][CH2:2][C:3]2([OH:1])[CH2:8][CH2:7][N:6]([C:9]([O:11][CH2:12][C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)=[O:10])[CH2:5][CH2:4]2)[CH:24]=[CH:25][CH:26]=1

Participants

4

Reactant 3

HCID 97423-FluoroanilineHCID 13016598Benzyl 1-oxa-6-azaspiro(2.5)octane-6-carboxylateHCID 23665649Lithium perchlorate

Product 1

HCID 56773836HCID 56773836, compound

Procedure

The object product (2.53 g, 94%) was obtained in the same manner as in Example 24(1) and using benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (1.98 g), 3-fluoroaniline (889 mg) and lithium perchlorate (960 mg).

Sources & evidence

ORD record
ord-ac1c70f968ad4db789ffcea3a44e01b8
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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