HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoroaniline → Benzyl 4-(((4-fluorophenyl)amino)methyl)-4-hydroxypiperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoroaniline | HCID 9731 | — |
| Reactant | Benzyl 1-oxa-6-azaspiro(2.5)octane-6-carboxylate | HCID 13016598 | — |
| Reactant | Lithium perchlorate | HCID 23665649 | — |
| Product | Benzyl 4-(((4-fluorophenyl)amino)methyl)-4-hydroxypiperidine-1-carboxylate | HCID 56773849 | — |
Reaction Steps
The object product (2.8 g, 98%) was obtained in the same manner as in Example 24(1) and using benzyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate (1.98 g), 4-fluoroaniline (889 mg) and lithium perchlorate (960 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575167B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-21db5bbe6f67459692392a7159629800 |
| Source note | uspto-grants-2013_11 |