1047656-01-8 → 1047656-03-0

HRID 2036100Notes

Reaction equation

HRID 2036100 reaction equation
[ClH:1].[NH:2]1[CH2:6][CH2:5][C:4]2([CH:15]=[CH:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[O:7]2)[CH2:3]1>CO.[C].[Pd]>[ClH:1].[NH:2]1[CH2:6][CH2:5][C:4]2([CH2:15][CH2:14][C:13]3[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=3)[O:7]2)[CH2:3]1

Participants

4

Reactant 1

HCID 685521291047656-01-8

Product 1

HCID 685550421047656-03-0Yield 86%

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

Spiro[chromene-2,3′-pyrrolidine] hydrochloride (150 mg) synthesized in Example 33(1) and 5% palladium-carbon (30 mg) were suspended in methanol (10 mL), and the suspension was stirred overnight under a hydrogen atmosphere at room temperature. The catalyst was removed by filtration through celite, and the solvent was evaporated under reduced pressure to give the object product (130 mg, 86%).

Workup

  1. customThe catalyst was removed by filtration through celite
  2. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-d62175440f334cfb87d01dd88cc4f2aa
Source dataset
uspto-grants-2013_11
Patent number
US08575167B2

Reaction notes

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