Water → HCID 68556599, compound

Participants

Reaction Conditions

Reaction Steps

3-Chloro-6-(3-methyl-1,2,4-oxadiazol-5-yl)pyridazine (690 mg) obtained in Example 43(2), spiro[3,1-benzoxazine-4,4′-piperidin]-2(1H)-one (1 g) and triethylamine (1.4 mL) were suspended in N,N-dimethylformamide (20 mL), and the suspension was stirred at 160° C. under irradiation of microwave for 15 min. The mixture was cooled to room temperature, water (200 mL) was added and the resulting precipitate was collected by filtration. The precipitate was recrystallized from ethanol to give the object product (550 mg, 42%).

Provenance & Evidence