Triphenylphosphine → HCID 68558983, compound

Participants

Reaction Conditions

Reaction Steps

(1-Benzyl-2,5-dihydro-1H-pyrrol-3-yl)methanol (11.44 g) obtained in Example 50(2), 2-bromo-5-trifluoromethylphenol (16.04 g), DEAD (40% toluene solution, 11.06 mL) and triphenylphosphine (18.95 g) were dissolved in tetrahydrofuran (450 mL). The reaction solution was stirred at 50° C. overnight. Tetrahydrofuran was evaporated under reduced pressure, and the residue was purified by silica gel column (10% ethyl acetate/petroleum ether to 20% ethyl acetate/petroleum ether) to give the object product as a white solid (12.3 g, 49%).

Provenance & Evidence