Hydrochloric Acid → HCID 58456728, compound

Participants

Reaction Steps

A solution of tert-butyl 4-(3,5-difluoro-4-((1-((3-(trifluoromethyl)-1,2,4-oxadiazol-5-yl)methyl)piperidin-4-yl)oxy)phenyl)-4-fluoropiperidine-1-carboxylate D1i in dichloromethane (5 mL) is treated with hydrogen chloride in dioxane (4 M solution; 0.1 mL, 0.4 mL). The mixture is stirred at room temperature for 1 hour and concentrated to yield 5-((4-(2,6-difluoro-4-(4-fluoropiperidin-4-yl)phenoxy)piperidin-1-yl)methyl)-3-(trifluoromethyl)-1,2,4-oxadiazole D1j (hydrochloride salt) as an oil. LCMS calcd. for C20H23F6N4O2+ ([M+H]+): 465.2, found: 465.2.

Provenance & Evidence