HCID 66655225, compound → HCID 86682580, compound

Participants

Reaction Steps

To a solution of (±)-1-(5-chloro-2-ethoxycarbonylmethoxy-phenyl)-5-fluoro-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester (165 mg, 0.34 mmol, 1.0 eq.) in AcOH (3.0 mL), 33% hydrobromic acid in acetic acid (3.0 mL) was added. The mixture was stirred at r.t. for 2 hours. The reaction mixture was concentrated in vacuo. The residue was stirred in 1.25M HCl in ethanol (5.0 mL) at r.t. for 18 hours. The reaction mixture was concentrated in vacuo to give the desired salt as a colorless oil.

Provenance & Evidence