HCID 66655016, compound → HCID 178516275, compound

Participants

Reaction Steps

A solution of (±)-1-[2-(3-benzyloxy-isoxazol-5-ylmethoxy)-5-chloro-phenyl]-3,4-dihydro-1H-isoquinoline-2-carboxylic acid benzyl ester (70 mg, 0.12 mmol, 1 eq.) in 33% hydrobromic acid in acetic acid (0.64 mL) was stirred at r.t. for 1.5 hours. The solvent was removed in vacuo. The residue, redissolved in MeCN/MeOH, was purified by prep. HPLC (column: Waters XBridge, 30×75 mm, 10 um, UV/MS, acidic conditions) and evaporated (genevac) to give (±)-5-[4-chloro-2-(1,2,3,4-tetrahydro-isoquinolin-1-yl)-phenoxymethyl]-isoxazol-3-ol.

Provenance & Evidence