HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester → HCID 67429987, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-2-(methylthio)pyrimidine-5-carboxylic acid ethyl ester | HCID 80008 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 1-Methyl-3-aminopyrazole | HCID 137254 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67429987 | HCID 67429987 | 81.3% |
Reaction Steps
To a solution of 800 mg of ethyl 4-chloro-2-(methylsulfanyl)pyrimidine-5-carboxylate in 20 mL of THF, 890 mg of DIPEA and 368 mg of 1-methyl-1H-pyrazol-3-amine were added, and the resulting mixture was stirred under reflux for 2 hours, and then, the solvent was distilled off. The thus obtained crude product was purified by silica gel column chromatography, whereby 820 mg the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575179B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-f1cd5f872e0849eeb3f6e024b985d9bd |
| Source note | uspto-grants-2013_11 |