HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Methyl (3-{[[4-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)butyl](2-hydroxy-2-methylpropyl)amino]sulfonyl}phenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Propanol, 1-amino-2-methyl- | HCID 95102 | — |
| Reactant | 9-(4-Bromobutyl)-2-butoxy-8-methoxyadenine | HCID 23158511 | — |
| Reactant | Methyl [3-(chlorosulfonyl)phenyl]acetate | HCID 23388821 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Methyl (3-{[[4-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)butyl](2-hydroxy-2-methylpropyl)amino]sulfonyl}phenyl)acetate | HCID 11713966 | — |
Reaction Steps
The compound obtained in Example 2-13 step (i) (371 mg) and 1-amino-2-methylpropane-2-ol (400 mg) were dissolved in acetonitrile (5 ml) and the same manner to Example 2-19 using triethylamine (0.055 ml) and methyl [3-(chlorosulfonyl)phenyl]acetate (93 mg) was conducted to give the titled compound as a white solid. Yield: 140 mg (24%); mp 192-193° C., MS APCI+ve 579 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08575180B2 |
| Source dataset | uspto-grants-2013_11 |
| ORD ID | ord-713dafe7ad5e4217940a32834467166b |
| Source note | uspto-grants-2013_11 |